ACETYLATE

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Traducere în limba română

acetylate verb tranzitiv

(chim.) a acetila.

Exemple de propoziții și/sau fraze:

Initially, the PCAF HAT-containing complex is recruited, and it acetylates the nucleosome.

(IFN-Beta Enhancer Pathway, NCI Thesaurus/BIOCARTA)

GD2, an O-acetylated disialoganglioside, belongs to the group of glycosphingolipids that are widely expressed in many tissues and organs in vertebrates and have been suggested to be involved in the regulation of development and differentiation as recognition molecules or signal modulators.

(Ganglioside GD2, NCI Thesaurus)

Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis.

(Abexinostat, NCI Thesaurus)

GD3, an O-acetylated disialoganglioside, belongs to the group of glycosphingolipids that are widely expressed in many tissues and organs in vertebrates and have been suggested to be involved in the regulation of development and differentiation as recognition molecules or signal modulators.

(Ganglioside GD3, NCI Thesaurus)

CHR-2845 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in chromatin remodeling, inhibition of tumor oncogene transcription, inhibition of tumor cell division, and the induction of tumor cell apoptosis.

(HDAC Inhibitor CHR-2845, NCI Thesaurus)

HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis.

(HDAC Inhibitor CHR-3996, NCI Thesaurus)

Although the exact therapeutic mechanism of action for CXD101 is not known, oral administration of this agent should inhibit the catalytic activity of HDAC, which results in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression.

(HDAC Inhibitor CXD101, NCI Thesaurus)

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