AFFINITY

Pronunție (USA): (GB):

Traducere în limba română

affinity substantiv

1. (with, between) afinitate, asemănare, analogie, înrudire, potrivire (cu, între), apropiere (de, între).

2. rudenie (prin alianţă).

3. înclinaţie, atracţie; afinitate electivă.

4. (chim.) afinitate.

5. (mat.) transformare afină.

Exemple de propoziții și/sau fraze:

A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity.

(Aprepitant, NCI Thesaurus)

Monoclonal antibody RG 83852 binds to the EGFR, inhibiting the high-affinity binding of epidermal growth factor (EGF) and receptor activation.

(Monoclonal Antibody RG 83852, NCI Thesaurus)

Eotaxin and eotaxin-2 are potent stimulators of eosinophils, signaling exclusively via high affinity binding to the receptor CCR3.

(Allergy Chemokine Network Pathway, NCI Thesaurus/BIOCARTA)

Higher affinity binding is achieved by association with the low-affinity neurotrophin receptors TRKA, TRKB, and TRKC.

(Nerve Growth Factor Receptor, NCI Thesaurus)

SHC3 and SCK mediate EGF signaling, but SHC3 has a higher affinity for TRKA and TRKB.

(Neuronal SHC, NCI Thesaurus)

Many affinity reagents are antibodies.

(Affinity reagent, NCI Dictionary)

The young man still replied: Come to the pollis! and was dragging me against the donkey in a violent manner, as if there were any affinity between that animal and a magistrate, when he changed his mind, jumped into the cart, sat upon my box, and, exclaiming that he would drive to the pollis straight, rattled away harder than ever.

(David Copperfield, de Charles Dickens)

But when this subject was succeeded by his account of Mr. Wickham—when she read with somewhat clearer attention a relation of events which, if true, must overthrow every cherished opinion of his worth, and which bore so alarming an affinity to his own history of himself—her feelings were yet more acutely painful and more difficult of definition.

(Pride and Prejudice, de Jane Austen)

In the CNS the antinociceptive activity of this agent may involve high affinity binding to and inhibition of N-methyl-D-aspartate (NMDA) receptors and/or the enhancement of the action of serotonin at the spinal terminals of an opioid-mediated intrinsic analgesia system.

(Amitriptyline hydrochloride, NCI Thesaurus)

The anti-ErB2 targeting arm of anti-ErbB2/anti-ErbB3 bispecific monoclonal antibody MM-111 binds to ErbB2 on tumor cells with high affinity while the anti-Erb3 therapeutic arm binds to ErbB3, which may result in the inhibition of cellular proliferation and differentiation in ErbB2-overexpressing tumor cells via inhibition of ErbB3-dependent signal transduction pathways.

(Anti-ErbB2/Anti-ErbB3 Bispecific Monoclonal Antibody MM-111, NCI Thesaurus)

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