BACKBONE

Pronunție (USA): (GB):

Traducere în limba română

backbone substantiv

1. coloană vertebrală, şira spinării;

(fig.) to the backbone până în măduva oaselor, complet, până la capăt; în toate cele; sadea.

2. (fig.) tărie de caracter, hotărâre, fermitate;

he lacks / wants backbone îi lipseşte tăria de caracter, n-are şira spinării.

3. (fig.) coloană vertebrală; sprijin; temelie;

the affair wants more backbone chestiunea trebuie sprijinită mai serios.

4. cotorul cărţii.

5. (ferov.) magistrală, cale ferată principală.

Exemple de propoziții și/sau fraze:

Enzymes that catalyze the hydrolytic cleavage of phosphodiester bond linkages in the DNA backbone.

(Deoxyribonuclease, NCI Thesaurus)

But mammal backbones are different.

(What makes a mammal a mammal? Our spine, say scientists, National Science Foundation)

When examined from the top of the helix, there is a large hole in the middle, the sugar phosphate backbone is at the edge of the helix, and the bases are displaced towards the edge.

(A-DNA, NCI Thesaurus)

Differing from traditional antisense oligodeoxynucleotides (ODNs), neutrally charged PMOs are composed of subunits of nucleic acid bases linked to a synthetic backbone and, so, are less prone to enzymatic degradation. c-Myc, a proto-oncogene overexpressed in a variety of cancers, is involved in cellular proliferation, differentiation, and apoptosis.

(Phosphorodiamidate Morpholino Oligomer AVI-4126, NCI Thesaurus)

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