BREAKAGE

Pronunție (USA): (GB):

Traducere în limba română

breakage substantiv

1. rupere, spargere, sfărâmare, avarie.

2. compensaţie sau reducere; rabat pentru mărfurile avariate.

3. (mine) abataj; sfărâmare (a rocei).

4. (text.) rupere a firului.

5. (mar.) spaţiu nefolosit.

Exemple de propoziții și/sau fraze:

Encoded by human NBS1 Gene, ubiquitous expression of 754-amino acid 85 kD Nibrin occurs principally in testis, thymus, and spleen (sites of physiologic DNA double-strand breakage) and liver, lung, striated/smooth muscle, kidney, and gut (high proliferative activity).

(Nibrin, NCI Thesaurus)

The milatuzumab moiety of this ADC selectively binds to CD74 on tumor cell surfaces; upon internalization, the doxorubicin moiety is released, where it intercalates between base pairs in the DNA helix and inhibits topoisomerase II, thereby preventing DNA replication and increasing double-strand breakage.

(Milatuzumab-Doxorubicin Antibody-Drug Conjugate, NCI Thesaurus)

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