CONJUGATED

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Traducere în limba română

conjugated adjectiv

(mat.) conjugat.

Exemple de propoziții și/sau fraze:

An immunoconjugate consisting of a humanized monoclonal antibody against the tumor-associated sialoglycotope CA6 (huDS6) conjugated to the cytotoxic maytansinoid DM4, with potential antineoplastic activity.

(Anti-CA6-DM4 Immunoconjugate SAR566658, NCI Thesaurus)

A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities.

(pan-PI3K/mTOR Inhibitor SF1126, NCI Thesaurus)

An immunoconjugate consisting of the humanized monoclonal antibody huMy9-6 conjugated to the cytotoxic maytansinoid DM4 with potential antineoplastic activity.

(Anti-CD33 Monoclonal Antibody-DM4 Conjugate AVE9633, NCI Thesaurus)

A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with lysate from autologous melanoma cells containing tumor associated antigens (TAAs) and conjugated to the immunostimulant Keyhole limpet hemocyanin (KLH), with potential immunostimulatory and antineoplastic activities.

(Autologous Melanoma Lysate/KLH-Pulsed Autologous Dendritic Cell Vaccine, NCI Thesaurus)

An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody (AGS-16C) directed to the ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3), conjugated via a non-cleavable linker to monomethyl auristatin F (MMAF), an auristatin derivative and a potent microtubule inhibitor, that has potential antineoplastic activity.

(Anti-ENPP3 Antibody-Drug Conjugate AGS-16C3F, NCI Thesaurus)

An antibody-drug conjugate (ADC) containing a monoclonal antibody directed against guanylyl cyclase C (GCC or GUCY2C) conjugated to monomethylauristatin E (MMAE), an auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic activity.

(Anti-GCC Antibody-Drug Conjugate MLN0264, NCI Thesaurus)

An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody, directed against the extracellular domain of the human CD70 molecule, conjugated to a prodrug of a CC-1065 (rachelmycin) analogue via a stable peptide-based linker, with potential antineoplastic activity.

(Anti-CD70 Antibody-Drug Conjugate MDX-1203, NCI Thesaurus)

An immunoconjugate consisting of a humanized monoclonal antibody that is engineered to contain cysteine residues that are conjugated to the synthetic, DNA cross-linking, pyrrolobenzodiazepine dimer SGD-1882, via the protease-cleavable linker maleimidocaproyl-valine-alanine dipeptide, with potential antineoplastic activity.

(Anti-CD33 Antibody-Drug Conjugate SGN-CD33A, NCI Thesaurus)

By binding to proteoglycan chondroitin sulfate-associated protein, monoclonal antibody Me1-14 F(ab')2 conjugated to a radioisotope may localize gliomas and melanomas when used as a tracer in radioimaging applications; in radioimmunotherapeutic applications, this agent conjugated to a radioisotope may be used to deliver targeted radiotoxicity to these tumors.

(Monoclonal Antibody Me1-14 F(ab')2, NCI Thesaurus)

An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed against the anti-solute carrier family 39 zinc transporter member 6 (SLC39A6; LIV-1; ZIP6) protein that is conjugated, via a protease-cleavable linker, to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity.

(Anti-LIV-1 Monoclonal Antibody-MMAE Conjugate SGN-LIV1A, NCI Thesaurus)

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