DEGRADATION

Pronunție (USA): (GB):

Traducere în limba română

degradation substantiv

1. degradare (şi tehn., chim)

2. decădere, declin.

3. (biol.) degenerare.

4. (geol.) dezintegrare (a rocilor).

5. (arte) degradare (a culorii).

6. scădere treptată / gradată.

Exemple de propoziții și/sau fraze:

At least part of the MYC box-directed degradation occurs via the proteasome.

(MYC Box, NCI Thesaurus)

Its tendency would be to raise and refine her mind—and it must be saving her from the danger of degradation.

(Emma, de Jane Austen)

This allele, which encodes neuralized-like protein 1, plays a role in the regulation of proteosome-mediated protein degradation.

(NEURL wt Allele, NCI Thesaurus)

Such was the contagiousness of degradation.

(Martin Eden, de Jack London)

Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity.

(Apoptosis Pathway, NCI Thesaurus/KEGG)

Nucleotide Metabolism Alteration involves a change in the quality of the existing state of activities of biologic molecules or complexes involved in the enzymatic formation or degradation of nucleoside phosphates, the monomeric building blocks from which DNA or RNA polymers are constructed.

(Nucleotide Metabolism Alteration, NCI Thesaurus)

Some say there is enjoyment in looking back to painful experience past; but at this day I can scarcely bear to review the times to which I allude: the moral degradation, blent with the physical suffering, form too distressing a recollection ever to be willingly dwelt on.

(Jane Eyre, de Charlotte Brontë)

In addition, after the internalization of this agent and lysosomal degradation, the DM1 moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and eventually causing cell death in CD37-positive B-cells.

(Anti-CD37 Antibody-Drug Conjugate IMGN529, NCI Thesaurus)

Sparing normal cells, apoptosis inducer BZL101 specifically facilitates translocation of the protein apoptosis-inducing factor (AIF) from the mitochondrial membrane into the nucleus in tumor cells, thereby causing tumor cell-specific chromatin condensation and DNA degradation followed by the induction of caspase-independent apoptosis.

(Apoptosis Inducer BZL101, NCI Thesaurus)

This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic.

(Arsenic trioxide, NCI Thesaurus)

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