DEPLETION

Pronunție (USA): (GB):

Traducere în limba română

depletion substantiv

1. golire, epuizare, istovire.

2. (med.) evacuare / curăţire a intestinelor; sângerare, luare de sânge.

Exemple de propoziții și/sau fraze:

Depletion of polyamines appears to reduce cell growth, and increased polyamine expression is associated with the cancer development and progression, making polyamine biosynthesis a target for the control of cancer.

(Biosynthesis of Spermidine and Spermine Pathway, NCI Thesaurus/BIOCARTA)

The study found that most of Greenland's rapid ice depletion is from a surprising source — land that is largely devoid of glaciers.

(Study: Greenland's Ice Melting Faster than Previously Thought, VOA)

That process causes more algae to grow, which sink to the bottom when they die and contribute to oxygen depletion of the water.

(Research reveals harmful algal blooms' daily cycles, National Science Foundation)

An antagonist of the neurotransmitter dopamine with potential antineoplastic activity. 6-Hydroxydopamine (6-HOD) can be taken up by selective adrenergic terminals, thereby causing acute degeneration of adrenergic terminals that leads to depletion of norepinephrine, and of dopamine in the dopamine-sensitive sites.

(Oxidopamine, NCI Thesaurus)

A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death.

(Folitixorin, NCI Thesaurus)

This theory might be supported by the discovery of the role of a mutant PRKAG2 gene in HCM, which in active form acts as a central sensing mechanism protecting cells from depletion of ATP supplies.

(Hypertrophic Cardiomyopathy Pathway, NCI Thesaurus/KEGG)

IDO, a cytosolic enzyme responsible for tryptophan catabolism and conversion of tryptophan into kynurenine, is overexpressed by a variety of tumor cell types and antigen presenting cells (APCs) and plays an important role in immunosuppression; Tryptophan depletion inhibits T-lymphocyte proliferation and activation, and suppresses the immune system.

(Indoleamine 2,3-dioxygenase Peptide Vaccine, NCI Thesaurus)

As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis.

(Aminopterin, NCI Thesaurus)

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