DISRUPTION

Pronunție (USA): (GB):

Traducere în limba română

disruption substantiv

1. ruptură, spărtură.

2. (ist. bis.) dezbinare, sciziune, schismă.

3. (geol.) descompunere, dezagregare, erodare, măcinare (a rocilor).

4. (electr.) străpungere, perforare.

Exemple de propoziții și/sau fraze:

Disruption of various cell signaling pathways may follow, eventually leading to the induction of apoptosis and inhibition of tumor growth.

(Oprozomib, NCI Thesaurus)

The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells.

(ALK Inhibitor CH5424802, NCI Thesaurus)

Asaley alkylates and crosslinks DNA, resulting in disruption of DNA synthesis.

(Asaley, NCI Thesaurus)

The discovery of a pathway for immune cells to exit the central nervous system raises the question of whether disruption of this route may be involved in neurological disorders that are associated with immune system dysfunction, such as multiple sclerosis, meningitis, and Alzheimer’s disease.

(Lymphatic Vessels Discovered in Central Nervous System, NIH)

Upon administration, inactive palladium-bacteriopheophorbide is activated locally when the tumor bed is exposed to photoirradiation; the activated form induces local cytotoxic processes, resulting in local tissue damage, disruption of tumor vasculature, and tumor hypoxia and necrosis.

(Palladium-Bacteriopheophorbide, NCI Thesaurus)

The monoclonal antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane antigen; MLN274 is then internalized into the tumor cell where the DM1 maytansinoid moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and cell death.

(MLN2704, NCI Thesaurus)

In addition, after the internalization of this agent and lysosomal degradation, the DM1 moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and eventually causing cell death in CD37-positive B-cells.

(Anti-CD37 Antibody-Drug Conjugate IMGN529, NCI Thesaurus)

Aurora A kinase inhibitor MK5108 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and eventually inhibition of cell division, proliferation and an induction of apoptosis in cells overexpressing Aurora A kinase.

(Aurora A Kinase Inhibitor MK5108, NCI Thesaurus)

Noscapine binds to tubulin and alters its conformation, resulting in a disruption of the dynamics of microtubule assembly (by increasing the time that microtubules spend idle in a paused state) and subsequently, the inhibition of mitosis and tumor cell death.

(Noscapine Hydrochloride, NCI Thesaurus)

Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.

(Midostaurin, NCI Thesaurus)

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