DOWNSTREAM

Pronunție (USA): (GB):

Traducere în limba română

downstream I. adverb

spre vărsarea apei, în aval.

downstream II. substantiv

(hidr.) capul aval al ecluzei.

Exemple de propoziții și/sau fraze:

RANK-ligand, also called osteoprotegerin-ligand, binds to RANK, induces receptor dimerization, and activates downstream signaling.

(Bone Remodeling Pathway, NCI Thesaurus/BIOCARTA)

The hyperpolarization of the membrane potential of the photoreceptor cell modulates the release of neurotransmitters to downstream cells.

(Phototransduction Pathway, NCI Thesaurus/KEGG)

Consequently, this disrupts phosphorylation of substrates downstream of PI3K and mTOR and may result in apoptosis and growth inhibition in susceptible tumor cells.

(PI3K/mTOR Kinase Inhibitor VS-5584, NCI Thesaurus)

Glut4 is used as an example of the downstream elements leading to changes in metabolism.

(PGC1a Regulation Pathway, NCI Thesaurus/BIOCARTA)

Like SRC and JAK family kinases, TNK1 mediates intracellular signaling downstream of receptor activation.

(Non-Receptor Tyrosine Kinase 1, NCI Thesaurus)

Production of prodynorphin is transcriptionally regulated by a downstream regulatory element (DRE) in the prodynorphin gene.

(Pain Repression Pathway, NCI Thesaurus/BIOCARTA)

P70S6K, a serine/threonine kinase, acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway, is often upregulated in a variety of cancer cells, and is involved in the regulation of cell growth, proliferation, motility, and survival.

(p70S6K Inhibitor LY2584702, NCI Thesaurus)

While increasing serotonin itself can have a broad impact on an animal's food intake, movement and reproductive behavior, the researchers found that increasing FLP-7 levels farther downstream didn't come with any obvious side effects.

(Scientists Find Brain Hormone That Triggers Fat Burning, Editura Global Info)

Pan-AKT kinase inhibitor GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis.

(Pan-AKT Kinase Inhibitor GSK690693, NCI Thesaurus)

As mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K, this agent may potentially be more potent than an agent that inhibits either PI3K kinase or mTOR kinase.

(pan-PI3K/mTOR Inhibitor PQR309, NCI Thesaurus)

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