INACTIVATE

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inactivate verb tranzitiv

( med.) (despre anumite activitaţi / substanţe biologice) a face inactiv.

Exemple de propoziții și/sau fraze:

During G2, Cdc2 is inactivated by Wee1 and Mt1 kinases.

(Negative Regulation of G2 to M Transition, NCI Thesaurus)

RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein.

(p21 H-Ras Protein, NCI Thesaurus)

Oxetacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall.

(Oxetacillin, NCI Thesaurus)

The inactivated form of HER3 blocks the PI3K/Akt signaling pathway, thereby inhibiting cellular proliferation in HER2 or NRG expressing tumor cells.

(Anti-HER3 Monoclonal Antibody LJM716, NCI Thesaurus)

Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells and inactivate the nuclear factor-kappa B (NF-kB)-mediated survival pathway.

(Birinapant, NCI Thesaurus)

Ampicillin, a broad-spectrum, semisynthetic penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.

(Ampicillin Sodium/Sulbactam Sodium, NCI Thesaurus)

Factors H and I cannot inactivate C3b on the cell surface due to protection by properdin, ensuring that the alternative pathway is primarily inactive in plasma and specifically activated on the surface of invading.

(Alternative Complement Pathway, NCI Thesaurus/BIOCARTA)

Following internalization, PAP, a plant hemitoxin and a ribosome-inactivating protein, is cleaved from the immunoconjugate and released into the cytoplasm where it enzymatically removes a single adenine base from a conserved, surface exposed loop sequence of rRNA leading to inhibition of protein synthesis and cell growth, but not necessarily cell death.

(B43-PAP immunotoxin, NCI Thesaurus)

IFN alpha is a type I interferon produced by peripheral blood leukocytes or lymphoblastoid cells when exposed to live or inactivated virus, double-stranded RNA, or bacterial products and is the primary interferon produced by virus-induced leukocyte cultures.

(Natural IFN-alpha OPC-18, NCI Thesaurus)

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