INDUCTION

Pronunție (USA): (GB):

Traducere în limba română

induction substantiv

1. instalare (într-o funcţie; într-o locuinţă etc.); punere în posesie.

2. (amer. mil.) înrolare.

3. (log.) inducţie, metodă indnctivă.

4. (electr.) inducţie;

self induction self inducţie.

5. (mec.) admisie, aspiraţie (a gazelor, a amestecului carburant etc.).

6. (med.) cauză (a unei stări, boli etc.).

7. induction of facts producere de fapte, expunere de probe.

Exemple de propoziții și/sau fraze:

This allele, which encodes NACHT, LRR and PYD domains-containing protein 1, is involved in apoptosis induction.

(NLRP1 wt Allele, NCI Thesaurus)

This gene plays a role in the induction of apoptosis.

(NLRP1 Gene, NCI Thesaurus)

Akt inhibitor GDC-0068 binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.

(Akt Inhibitor GDC-0068, NCI Thesaurus)

Subsequently, aminoflavone is metabolized to toxic metabolites by the cytochromome P450 enzymes that it induces; these toxic metabolites covalently bind to DNA, resulting in the phosphorylation of p53, the induction of the p53 downstream target p21Waf1/Cip1, and apoptosis.

(AFP464, NCI Thesaurus)

AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis.

(AEE788, NCI Thesaurus)

Multitargeted tyrosine kinase inhibitor BIBF 1120 selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases, which may result in the induction of endothelial cell apoptosis; a reduction in tumor vasculature; and the inhibition of tumor cell proliferation and migration.

(Nintedanib, NCI Thesaurus)

Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.

(Akt Inhibitor GSK2141795, NCI Thesaurus)

Expression of REIC/DKK3 is normal in healthy cells but reduced or absent in many cancer cells; Forced overexpression of REIC/DKK3 in cancer cells may lead to an induction of tumor cell apoptosis and reduction of tumor cell growth while sparing normal, healthy cells naturally expressing endogenous REIC/DKK3.

(Ad-REIC/DKK3 Vaccine, NCI Thesaurus)

Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis.

(Abexinostat, NCI Thesaurus)

An orally available inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor CC-223 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/AKT/mTOR signaling pathway, which is frequently dysregulated in human cancers.

(mTOR Kinase Inhibitor CC-223, NCI Thesaurus)

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