INSTABILITY

Pronunție (USA): (GB):

Traducere în limba română

instability substantiv

1. (tehn.) instabilitate, lipsă de stabilitate / de echilibru, dezechilibrare, echilibru prost.

2. nestabilitate, nestatornicie, mobilitate, labilitate, inconstanţă;

instability of human affairs nestatornicia lucrurilor omeneşti.

3. lipsă de trăinicie (a unui pod etc.).

Exemple de propoziții și/sau fraze:

Niraparib inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis.

(Niraparib, NCI Thesaurus)

Some authors have suggested that it is a precursor lesion for some colonic adenocarcinomas with microsatellite instability.

(Colon Sessile Serrated Adenoma/Polyp, NCI Thesaurus)

A dinucleotide repeat on chromosome 17 that serves as a marker for microsatellite instability in colorectal cancers.

(D17S250, NCI Thesaurus)

This type of mutation, called “repeat instability,” may be useful in early cancer diagnosis.

(Researchers uncover role of repetitive DNA and protein sequences in tumor evolution, National Institutes of Health)

Variant allelic overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

(CCNE1 wt Allele, NCI Thesaurus)

This may lead to an accumulation of damaged DNA and may promote genomic instability and apoptosis.

(Checkpoint Kinase 1 Inhibitor LY2606368, NCI Thesaurus)

Also called microsatellite instability.

(MSI, NCI Dictionary)

My dear Copperfield, said Mr. Micawber, putting out his hand, this is indeed a meeting which is calculated to impress the mind with a sense of the instability and uncertainty of all human—in short, it is a most extraordinary meeting.

(David Copperfield, de Charles Dickens)

The subsequent decrease in the amount of formed microtubules causes disassembly of the mitotic spindle resulting from instability of the structure during the mitotic interphase, eventually leading to cell cycle arrest and/or apoptosis.

(Maytansine-Site Binding Agent, NCI Thesaurus)

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