INTEGRAL

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Traducere în limba română

integral I. adjectiv

1. integral; întreg, complet;

to form an integral part of a se integra, a fi (o) parte integrantă din / a (cu gen.).

2. alcătuit din mai multe părţi, compus.

3. esenţial, absolut necesar, cu neputinţă de eliminat.

4. (mat.) integral.

integral II. substantiv

1. întreg, tot, totalitate.

2. (mat.) integrală.

Exemple de propoziții și/sau fraze:

Isoform 3 may exist as an integral membrane protein that undergoes slow proteolysis at the cell surface to yield a soluble growth factor.

(Colony Stimulating Factor 1, NCI Thesaurus)

This integral membrane protein plays a role in transport and is associated with drug resistance in tumor cell lines.

(ATP-Binding Cassette, Sub-Family G, Member 2, NCI Thesaurus)

The cellular receptor of MV is human CD46 antigen, a type 1 integral membrane glycoprotein found on nearly all human tissues and overexpressed on many cancer cell types.

(Carcinoembryonic Antigen-Expressing Measles Virus, NCI Thesaurus)

Human ERCC2 Gene (RAD3/XPD Family) encodes 760-aa 87-kDa nuclear DNA Excision Repair Protein ERCC2, an ATP-dependent 5 prime-3 prime DNA helicase and one of six integral subunits of the basal transcription factor BTF2/TFIIH complex.

(ERCC2 Gene, NCI Thesaurus)

Expressed in germ cells in the testis by human BRS3 Gene (GPCR1 Family), 399-aa 44-kDa integral membrane protein Bombesin-like Receptor 3 is specifically activated by bombesin-like peptides and associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

(Bombesin-like Receptor 3, NCI Thesaurus)

As integral components of the late G1 restriction point, the Rb gene product and p16 are negative regulators of the cell cycle; ovarian cancer cells and non-small cell lung cancer cells may be defective in the Rb/p16 pathway.

(Oncolytic Ad5-Delta 24RGD, NCI Thesaurus)

Widely expressed by human ADORA3 Gene (GPCR1 Family), 318-aa 36-kDa Adenosine A3 Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains and 3 potential N-glycosylation sites that interacts with a heterotrimeric G protein complex in response to adenosine ligand to suppress cAMP accumulation through adenylate cyclase inhibition.

(Adenosine Receptor A3, NCI Thesaurus)

CD-40, an integral membrane protein found on the surface of B lymphocytes and member of the tumor necrosis factor receptor super-family, is highly overexpressed on the cell surface of a number of B-cell malignancies.

(Monoclonal Antibody SGN-14, NCI Thesaurus)

Each cell-surface integral membrane protein receptor contains a 7 transmembrane domain and interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate or suppress cAMP accumulation through adenylate cyclase activation or inhibition.

(Adenosine Receptor, NCI Thesaurus)

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