INTRACELLULAR

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Traducere în limba română

intracellular adjectiv

(biol.) intracelular.

Exemple de propoziții și/sau fraze:

Activation of Notch receptors by DLL4 stimulates proteolytic cleavage of the Notch intracellular domain (NICD); after cleavage, NICD is translocated to the nucleus and mediates the transcriptional regulation of a variety of genes involved in vascular development.

(Anti-DLL4 Monoclonal Antibody MEDI0639, NCI Thesaurus)

Anti-melanin monoclonal antibody PTI-6D2 binds to extracellular melanin, a melanocyte pigment which is released during tumor cell turnover from dead melanoma tumor cells, while avoiding the binding of melanin in normal, healthy tissue because of melanin's normal intracellular location.

(Anti-Melanin Monoclonal Antibody PTI-6D2, NCI Thesaurus)

Although the exact mechanism of action remains to be fully elucidated, ambazone appears to interfere with the membrane-bound nucleotide system by increasing the intracellular concentration of cAMP in leukemia cells and macrophages, which potentially contributes to this agent's antineoplastic activity.

(Ambazone, NCI Thesaurus)

Galectin-3, a chimeric molecule consisting of both carbohydrate recognition and collagen-like domains, interacts with a variety of carbohydrate and protein ligands to form pentamers with unique crosslinking abilities; this lectin also exhibits anti-apoptotic properties, perhaps, in part, through the regulation of intracellular signaling pathways.

(Apoptosis Inducer GCS-100, NCI Thesaurus)

IMPDH catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, and treatment with merimepodib reduces the intracellular guanine nucleotide levels that are required for RNA and DNA synthesis, resulting in antiproliferative and antiviral effect.

(Merimepodib, NCI Thesaurus)

In turn, this stimulates calcium ion influx through voltage-gated calcium channels, raising intracellular calcium ion levels and leading to the release of insulin-containing granules The IKATP channels found in pancreatic islets are complexes of four IKATP 6.2 and four SUR1 subunits.

(Meglitinide Antidiabetic Agent, NCI Thesaurus)

Arginine vasopressin receptor 1B protein (441 aa, 48 kD) is a cell communication process protein that is encoded by the human AVPR1B gene and has a roles in signal transduction through activation of phospholipase C and elevation of intracellular calcium.

(Arginine Vasopressin Receptor 1B, NCI Thesaurus)

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