KINASE

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Traducere în limba română

kinase substantiv

(biol.) kinază.

Exemple de propoziții și/sau fraze:

MELK, a serine/threonine kinase, is involved in cancer cell survival, invasiveness and cancer-stem cell formation and maintenance; it is highly upregulated in various types of cancer cells and absent in normal, healthy cells.

(MELK Inhibitor OTS167, NCI Thesaurus)

MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.

(MET Tyrosine Kinase Inhibitor BMS-777607, NCI Thesaurus)

Encoded by growth factor and E2F-regulated widely expressed human ASK Gene, 77-kD nuclear Activator of S Phase Kinase (dup) is a cyclin-like regulatory subunit of CDC7L1 kinase involved in G1/S transition.

(Activator of S Phase Kinase, NCI Thesaurus)

MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway that regulates cell growth and are often upregulated in a variety of tumor cell types.

(MEK 1/2 Inhibitor AS703988/MSC2015103B, NCI Thesaurus)

MEK, a dual specificity threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.

(MEK Inhibitor RO4987655, NCI Thesaurus)

An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), preventing phosphorylation and activation of the Mitogen-Activated Protein Kinase (MAPK) pathways, involved with signal transduction pathways and tumor proliferation.

(MEK Inhibitor CI-1040, NCI Thesaurus)

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