MAMMALIAN

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Traducere în limba română

mammalian (zool.) I. adjectiv

mamifer.

mammalian (zool.) II. substantiv

mamifer.

Exemple de propoziții și/sau fraze:

The drug rapamycin acts on mammalian cells through the mTOR protein kinase, also known as FRAP.

(mTOR Signaling Pathway BioCarta, NCI Thesaurus/BIOCARTA)

Mammalian P-glycoproteins are encoded by small MDR gene families.

(Multidrug Resistance Gene, NLM, Medical Subject Headings)

It was specific to mosquitoes; it didn’t affect any mammalian potassium channels tested.

(Novel insecticide blocks mosquitoes’ ability to urinate, NIH)

These ‘Regeneration-Organizing Cells’ help to explain one of the great mysteries of nature and may offer clues about how this ability might be achieved in mammalian tissues.

(Scientists find new type of cell that helps tadpoles’ tails regenerate, University of Cambridge)

The cell-surface receptor EphA2, a member of the ephrin family of receptor tyrosine kinases (RTKs) involved in mammalian development, is overexpressed by a variety of different cancer cell types and plays an important role in tumor growth.

(EphA2-targeting DOPC-encapsulated siRNA, NCI Thesaurus)

The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK.

(pan-PI3K/mTOR Inhibitor SF1126, NCI Thesaurus)

AKT1/2 inhibitor BAY1125976 selectively binds to and inhibits the phosphorylation and activity of AKT1/2 in a non-ATP competitive manner, which may result in the inhibition of the phosphatidylinositol 3 (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway.

(AKT 1/2 Inhibitor BAY1125976, NCI Thesaurus)

In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase.

(Everolimus, NCI Thesaurus)

An orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD2014 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/Akt/mTOR signaling pathway.

(mTOR Kinase Inhibitor AZD2014, NCI Thesaurus)

Any substance that inhibits mammalian target of rapamycin (mTOR or FK506 binding protein 12-rapamycin associated protein 1 (FRAP1)), a serine/threonine protein kinase that is active in the control of cell growth, cell proliferation, and cell motility.

(mTOR inhibitor, NCI Thesaurus)

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