MEDIATE

Pronunție (USA): (GB):

Traducere în limba română

mediate I. adjectiv

1. intermediar.

2. care necesită intermediul cuiva.

mediate II. verb A. intranzitiv

1. a ocupa o poziţie intermediară / de mijloc.

2. a face pe intermediarul / mediatorul / mijlocitorul, a mijloci.

mediate II. verb B. tranzitiv

a mijloci, a realiza prin intermediul cuiva.

Exemple de propoziții și/sau fraze:

IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells, inducing the secretion of interferon-gamma and inducing a cytotoxic T lymphocyte response against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation.

(Adenoviral Transduced hIL-12-expressing Autologous Dendritic Cells INXN-3001 Plus Activator Ligand INXN-1001, NCI Thesaurus)

Mr. Ford, with an expression on his mobile features of mediate and happy acquiescence, started to reach for his pocket, then turned suddenly to Mr. Ends, and said that he had left his money home.

(Martin Eden, de Jack London)

The international team, led by the University of Cambridge, found that calcium can mediate the interaction between small membranous structures inside nerve endings, which are important for neuronal signalling in the brain, and alpha-synuclein, the protein associated with Parkinson's disease.

(Calcium May Play A Role in Development of Parkinson's Disease, Editura Global Info)

Previous studies have suggested that both coffee and tea play an important role in modulating disease-risk in humans by suppressing tumor progression, decreasing inflammation and influencing estrogen metabolism, mechanisms that may be mediated by epigenetic changes.

(Tea Consumption: Epigenetic Changes in Women, Editura Global Info)

MEK1/2 inhibitor AS703988/MSC2015103B selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK 1/2 Inhibitor AS703988/MSC2015103B, NCI Thesaurus)

N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels.

(ADH-1, NCI Thesaurus)

Upon intradermal administration of the AdGMCAIX-transduced autologous DCs back into the patient, the DCs activate the immune system to both mount a cytotoxic T lymphocyte-mediated response against tumor cells positive for the CA9 antigen, and generate memory T cells.

(AdGMCAIX-transduced Autologous Dendritic Cells, NCI Thesaurus)

IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma and inducing cytotoxic T cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation.

(Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001, NCI Thesaurus)

Upon administration, adenovirus encoding rat HER-2/neu may induce an immune response against tumor cells expressing the HER-2/neu antigen, which may result in the immune-mediated inhibition of tumor cell proliferation and tumor cell death.

(Adenovirus Encoding Rat HER-2/neu, NCI Thesaurus)

MEK inhibitor TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK Inhibitor TAK-733, NCI Thesaurus)

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