MEDIATOR

Pronunție (USA): (GB):

Traducere în limba română

mediator substantiv

mijlocitor, mediator, intermediar.

Exemple de propoziții și/sau fraze:

IL 1a, an inflammatory mediator, plays a key role in interleukin-mediated tumor cell activity such as metastasis and tumor cell invasion.

(Anti-IL-1 alpha Monoclonal Antibody MABp1, NCI Thesaurus)

This results in synthesis of anti-inflammatory mediators while inhibiting synthesis of inflammatory mediators.

(Amcinonide, NCI Thesaurus)

The research group study analysed the changes in the expression of the so-called ‘clock genes’ (those that regulate the function of every cell in the body) of sepsis patients and the connection between these changes and the degree of inflammatory response, oxidative damage, and urinary excretion of 6-sulfatoxymelatonin—the major melatonin metabolite and mediator of clock genes.

(New study sheds fresh light on the genetic mechanisms involved in sepsis, the leading cause of death in ICUs, University of Granada)

As a consequence, the synthesis and release of Th1- (T helper 1) and Th2- (T helper 2) type cytokines, and other inflammatory mediators from T-cells and mast cells are blocked and the expression of signals essential for the activation of inflammatory T-lymphocytes is inhibited.

(Pimecrolimus, NCI Thesaurus)

Increasingly, research has indicated that gut microbiota—the trillions of microorganisms in the gut which perform important functions in the immune system and metabolism by providing essential inflammatory mediators, nutrients and vitamins—can help regulate brain function through something called the gut-brain axis.

(Anxiety May Be Alleviated by Changing Gut Bacteria, Editura Global Info)

IgE binds the high affinity IgE receptor at the surface of mast cells, the proliferation and differentiation of which is promoted by IL-9.The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy.

(Asthma Pathway, NCI Thesaurus/KEGG)

The long-acting beta-adrenergic receptor agonist formoterol selectively binds to beta-2 adrenergic receptors in bronchial smooth muscle, activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP); increased intracellular cAMP result in the relaxation of bronchial smooth muscle and inhibition of the cellular release of mediators of immediate hypersensitivity, especially from mast cells.

(Budesonide/Formoterol Fumarate Dihydrate Inhalation Aerosol, NCI Thesaurus)

This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.. Specifically, mometasone furoate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2.

(Mometasone furoate, NCI Thesaurus)

Upon oral administration, the polyphenols, and other active ingredients in this supplement may exert anti-inflammatory activity by decreasing the production of inflammation mediators, such as TNF-alpha, interleukin (IL) 1-beta, IL-6, IL-10, interferon gamma, thromboxane B2, and leukotriene B4.

(Olive Oil Extract/Curcumin-based Capsule, NCI Thesaurus)

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