METABOLIZE

Pronunție (USA): (GB):

Traducere în limba română

metabolize verb tranzitiv

a transforma (un ţesut) prin metabolism.

Exemple de propoziții și/sau fraze:

Upon intravenous administration of pegylated recombinant human arginase I BCT-100, arginase metabolizes the amino acid arginine to ornithine and urea, depleting intracellular arginine, which may inhibit proliferation of cells that are auxotrophic for arginine such as hepatocellular carcinoma (HCC) cells.

(Pegylated Recombinant Human Arginase I BCT-100, NCI Thesaurus)

As a prodrug, capecitabine is converted to 5'-deoxy-5-fluorocytidine (5'-DFCR) by hepatic carboxylesterase and then to 5'-deoxy-5-fluorouridine (5'-DFUR) by cytidine deaminase and is eventually activated by thymidine phosphorylase to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP).

(Capecitabine Rapidly Disintegrating Tablet, NCI Thesaurus)

Subsequently, aminoflavone is metabolized to toxic metabolites by the cytochromome P450 enzymes that it induces; these toxic metabolites covalently bind to DNA, resulting in the phosphorylation of p53, the induction of the p53 downstream target p21Waf1/Cip1, and apoptosis.

(AFP464, NCI Thesaurus)

In animals, P450 enzymes metabolize drugs, make steroid hormones, and defend against pollutants, says biologist John Stegeman, senior author of the paper and director of the Woods Hole Center for Oceans and Human Health.

(Surprising enzymes discovered in giant ocean viruses, National Science Foundation)

As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells.

(Capecitabine, NCI Thesaurus)

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