MODIFICATION

Pronunție (USA): (GB):

Traducere în limba română

modification substantiv

1. schimbare, modificare.

2. (lingv. ) apofonie, alternantă vocalică.

Exemple de propoziții și/sau fraze:

Other forms of post-translational protein modification such as phosphorylation are reversible in nature, but as of yet a protein demethylase is not known.

(CARM1 Transcription Regulation Pathway, NCI Thesaurus/BIOCARTA)

Only following infection are modifications in the landscape made that enable T cells to launch their attack.

(Rapid-response immune cells are fully prepared before invasion strikes, NIH)

They showed that TET1 activates a chemical switch - known as an epigenetic modification - on the ductal cell's DNA.

(Regeneration mechanism discovered in mice could provide target for drugs to combat chronic liver disease, University of Cambridge)

Cocaine was previously shown to cause specific histone modifications called histone methylation, but the regulation of histone methylation hadn't yet been investigated.

(What Causes Cocaine Addiction, NIH, US)

Previous studies have shown that levels of one type of epigenetic modification, called DNA methylation, roughly reflect a person’s age.

(DNA changes predict longevity, NIH)

Epigenetic changes are chemical modifications that turn our genes off or on.

(Tea Consumption: Epigenetic Changes in Women, Editura Global Info)

Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover.

(Alendronate sodium, NCI Thesaurus)

A modification of the standard method of allogeneic hematopoietic stem cell transplantation developed to allow for the therapy to be extended to a patient population that is unable to tolerate treatment with the conventional procedure due to its toxicity.

(Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation, NCI Thesaurus)

In animal models, such modifications were associated with improved in vivo stability, oral bioavailability, and markedly decreased concentration-related adverse events that were common for the first generation of oligonucleotides and have been attributed to sequence-independent and sequence-specific effects.

(Mixed-Backbone Oligonucleotide, NCI Thesaurus)

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