MUTATE

Pronunție (USA): (GB):

Traducere în limba română

mutate I. verb A. tranzitiv

1. a schimba, a modifica, a varia.

2. (fon.) a provoca mutaţia (unui sunet).

mutate I. verb B. intranzitiv

a se schimba, a se modifica; (fon.) a suferi o schimbare.

mutate II. adjectiv

schimbat, modificat.

Exemple de propoziții și/sau fraze:

BRAF (V600E) kinase inhibitor RO5185426 blocks this mutated protein, which may stop the growth of cancer cells.

(BRAF (V600E) kinase inhibitor RO5185426, NCI Dictionary)

Human Oncogene LCK is a mutated variant of LCK Gene, which encodes p56LCK, a lymphocyte-specific tyrosine protein kinase with an SH2 and SH3 domain.

(Oncogene LCK, NCI Thesaurus)

Human Oncogene ErbB2 is a mutated variant of ERBB2 Gene, which encodes ERRB2 Receptor Protein Tyrosine Kinase, a 185-kDa type I membrane glycoprotein similar to EGFR that controls cell growth.

(Oncogene ErbB2, NCI Thesaurus)

Human Oncogene FGR is a mutated variant of FGR Gene (SRC Family), which encodes 529-aa 60-kDa p55-FGR, a protein tyrosine kinase that may bind PTPNS1 and contains 1 SH2 and 1 SH3 domain.

(Oncogene FGR, NCI Thesaurus)

Mutated (changed) forms of the ALK gene and protein have been found in some types of cancer, including neuroblastoma, non-small cell lung cancer, and anaplastic large cell lymphoma.

(ALK gene, NCI Dictionary)

Yeast cell research was essential to the discovery, as these cells contain the same 'Ras' proteins commonly found in tumor cells, which can cause cancer in mutated form.

(Scientists Reveal The Relationship Between Sugar, Cancer, Editura Global Info)

Human Oncogene LMYC is a mutated variant of LMYC Gene (MYC Family), which encodes L-MYC Protein, a bZIP transcription factor that binds to DNA as a heterodimer with MAX; DNA binding requires dimerization with another bHLH protein.

(Oncogene LMYC, NCI Thesaurus)

Human Oncogene FPS-FES is a mutated variant of FES Gene (FES/FPS Subfamily), which encodes 822 aa 93-kDa Tyrosine-Protein Kinase FES/FPS, a tyrosine-specific protein kinase involved in normal hematopoiesis and containing an FCH and SH2 domain.

(Oncogene FPS-FES, NCI Thesaurus)

Human Oncogene K-Ras is a mutated variant of KRAS2 Gene, which encodes two alternative isoforms of monomeric p21 K-RAS protein, a monomeric GTPase involved in transmembrane signal transduction that alternates between inactive GDP-bound and active GTP-bound forms.

(Oncogene K-Ras, NCI Thesaurus)

The protein MDM2, a negative regulator of p53 activity, is overexpressed in many cancer cell types; the tumor suppressor p53 is mutated or deleted in about 50% of all cancers but active in the other 50%.

(Nutlin-3a, NCI Thesaurus)

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