NUCLEAR

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nuclear adjectiv

(fiz.) nuclear.

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In most people, genetic variants in both our nuclear and mitochondrial DNA come from the same part of the world.

(Interplay between mitochondria and the nucleus may have implications for changing cell’s ‘batteries’, University of Cambridge)

Encoded by human AMSH Gene, ubiquitously expressed 424-amino acid AMSH Protein contains two potential SH3-binding domains (PxxP motifs), a JAB1 subdomain homologous (JSH) region, and a putative nuclear localization signal.

(AMSH Protein, NCI Thesaurus)

The nuclear matrix, or scaffold, is a protein network in the nucleus providing structure and regulating chromatin condensation.

(AKAP8 in Mitosis Pathway, NCI Thesaurus/BIOCARTA)

Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells.

(Alitretinoin, NCI Thesaurus)

The researchers observed in the mice that very early in the disease process, the microglia infiltrate a layer of the retina near the photoreceptors, called the outer nuclear layer, where they don’t usually venture.

(In blinding eye disease, trash-collecting cells go awry, accelerate damage, NIH)

This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL protein, including the AT hook DNA binding domain and the DNA methyltransferase domain, fused to most of the SAP domain-containing ribonucleoprotein, including the SAP and nuclear localization domains.

(MLL/SARNP Fusion Protein, NCI Thesaurus)

This protein is comprised of the signal peptide of the LDLR chaperone MESD protein, fused to all but the first 8 amino acids of the sentrin-specific protease 1 protein, including the nuclear localization and protease domains.

(MESDC2/SENP1 Fusion Protein, NCI Thesaurus)

Encoded by growth factor and E2F-regulated widely expressed human ASK Gene, 77-kD nuclear Activator of S Phase Kinase (dup) is a cyclin-like regulatory subunit of CDC7L1 kinase involved in G1/S transition.

(Activator of S Phase Kinase, NCI Thesaurus)

The increase in secreted biologically active VEGF protein from cells exposed to hypoxia is partly because of an increased transcription rate, mediated by binding of hypoxia-inducible factor-1 (HIF1) to a hypoxia responsive element in the 5'-flanking region of the VEGF gene. bHLH-PAS transcription factor that interacts with the Ah receptor nuclear translocator (Arnt), and its predicted amino acid sequence, exhibits significant similarity to the hypoxia-inducible factor 1alpha (HIF1a) product.

(Angiogenesis Pathway, NCI Thesaurus/BIOCARTA)

A specific domain of AKAP95 regulates its interaction with the nuclear matrix and another regulates its association with DNA.

(AKAP8 in Mitosis Pathway, NCI Thesaurus/BIOCARTA)

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