PROMOTER

Pronunție (USA): (GB):

Traducere în limba română

promoter substantiv

1. persoană sau lucru care favorizează ceva; iniţiator, autor (al unui proiect); fondator, întemeietor (al unei societăţi), animator; promotor.

2. autor de proiecte năstruşnice.

3. (chim.) promotor, activator, accelerator.

4. (constr.) beneficiar, proprietar.

Exemple de propoziții și/sau fraze:

The general transcription factors and PolII form a multiprotein complex near the transcription start site by interacting with core promoter elements.

(Basal Transcription Factor Gene, NCI Thesaurus)

Burkitt's lymphoma is associated with at least three translocations, t(2;8)(p12;q24), t(8;14)(q24;q32) and t(8;22)(q24;q11) which fuse the gene to the promoter site for either the immunoglobin heavy or light chain genes.

(MYC wt Allele, NCI Thesaurus)

One marker of keratinocyte differentiation, the p21 gene, is activated by NFAT by a different mechanism, with NFAT activating the p21 promoter by acting as a coactivator for the transcription factors Sp1 and Sp3.Another protein activated by calcium that may be involved in keratinocyte differentiation is protein kinase C (PKC).

(Calcineurin Pathway, NCI Thesaurus/BIOCARTA)

Endothelial cell-specific transcriptional control of the adenoviral vector is achieved by the use of a modified murine PPE-1 promoter that is specifically activated in PPE-1-expressing angiogenic endothelial cells residing in the tumor microvasculature.

(Angiogenesis Inhibitor GT-111, NCI Thesaurus)

Human autologous peripheral blood lymphocytes (PBLs) transduced with two retroviral vectors, one encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1 and a second that encodes an inducible single chain form of interleukin-12 (IL-12) driven by a nuclear factor of activated T-cells (NFAT)-responsive promoter, with potential immunomodulating and antineoplastic activities.

(Autologous Peripheral Blood Lymphocytes Cotransduced with Retroviral Vectors Encoding Inducible IL-12 and Anti-NY-ESO-1 TCR, NCI Thesaurus)

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