PROTEIN

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Traducere în limba română

protein substantiv

(chim.) proteină, albumină.

Exemple de propoziții și/sau fraze:

By combining these variants into a ‘score’ for that protein, they were able to identify new associations between proteins and disease.

(Scientists create ‘genetic atlas’ of proteins in human blood, University of Cambridge)

The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells.

(A Kinase Anchor Protein 12, NCI Thesaurus/LocusLink)

MEK inhibitor WX-554 selectively binds to and inhibits the activity of MEK, thereby preventing the activation of MEK-dependent effector proteins including some transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK Inhibitor WX-554, NCI Thesaurus)

A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity.

(Abatacept, NCI Thesaurus)

On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).

(ABC Transporter Pathway, NCI Thesaurus/KEGG)

MEK inhibitor TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK Inhibitor TAK-733, NCI Thesaurus)

An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), preventing phosphorylation and activation of the Mitogen-Activated Protein Kinase (MAPK) pathways, involved with signal transduction pathways and tumor proliferation.

(MEK Inhibitor CI-1040, NCI Thesaurus)

MEK1/2 inhibitor AS703988/MSC2015103B selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK 1/2 Inhibitor AS703988/MSC2015103B, NCI Thesaurus)

The team also determined that one of the bNAbs, EBOV-520, recognizes and binds to a portion of virus GP in such a way that prevents it from interacting with a cell surface protein called NPC1 and initiating the infection cycle.

(Broadly acting antibodies found in plasma of Ebola survivors, National Institutes of Health)

By linking drugs, proteins, genetic variation and diseases, the team has suggested existing drugs that could potentially also be used to treat a different disease, and increased confidence that certain drugs currently in development might be successful in clinical trials.

(Scientists create ‘genetic atlas’ of proteins in human blood, University of Cambridge)

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