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They tested two types of iPS-CMs: early stage (12-day old cells) and late stage (28-day old mature cells) under three different scenarios.
(Early stimulation improves performance of bioengineered human heart cells, National Institutes of Health)
The researchers found that the third scenario, introducing physical conditioning at an increasing intensity to early stage iPS-CMs, helped them form adult-like human cardiac tissue after just four weeks of culture in the lab.
(Early stimulation improves performance of bioengineered human heart cells, National Institutes of Health)