SUPPRESSOR

Pronunție (USA): (GB):

Traducere în limba română

suppressor substantiv

1. persoană care înăbuşă (o revoltă etc.).

2. disimulator (al unui fapt).

Exemple de propoziții și/sau fraze:

Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers.

(ANP32C Protein, NCI Thesaurus/LocusLink)

A type of gene that makes a protein called a tumor suppressor protein that helps control cell growth.

(Antioncogene, NCI Dictionary)

The VHL tumor suppressor (von Hippel-Lindau) regulates also VEGF expression at a post-transcriptional level.

(Angiogenesis Pathway, NCI Thesaurus/BIOCARTA)

Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis.

(Abexinostat, NCI Thesaurus)

There are three types recognized: type 1 (MEN 1), caused by inactivation of the tumor suppressor gene MEN-1, type 2A (MEN 2A), caused by mutation of the RET gene, and type 2B (MEN 2B) also caused by mutation of the RET gene.

(Multiple Endocrine Neoplasia, NCI Thesaurus)

To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), DNA repair factors (RAD50, RAD51, GADD45), and other signaling molecules (c-Abl and NF-kB).

(ATM Signaling Pathway, NCI Thesaurus/BIOCARTA)

Mocetinostat binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others.

(Mocetinostat, NCI Thesaurus)

After cell entry, the first 12 amino acid residues interact with tumor suppressor p53 and form a p28:p53 complex, which may result in a reduction of proteasomal degradation of p53, increased p53 levels, and p53-mediated cell cycle inhibition and apoptosis.

(Azurin:50-77 Cell Penetrating Peptide p28, NCI Thesaurus)

Also called tumor suppressor gene.

(Antioncogene, NCI Dictionary)

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