TARGET

Pronunție (USA): (GB):

Traducere în limba română

target substantiv

ţintă (pentru ochit);

to shoot /to fire at the target a trage la ţintă;

moving target ţintă mişcătoare / mobilă;

(fig.) to be the target for popular ridicule a fi ţinta ironiilor publicului.

2. sarcină, plan;

to beat the target a depăşi planul.

3. (ferov.) semnal de zi.

4. (tehn.) şuber, clapetă, registru.

5. v. targe.

6. (electr.) anticatod.

Exemple de propoziții și/sau fraze:

AKT1/2 inhibitor BAY1125976 selectively binds to and inhibits the phosphorylation and activity of AKT1/2 in a non-ATP competitive manner, which may result in the inhibition of the phosphatidylinositol 3 (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway.

(AKT 1/2 Inhibitor BAY1125976, NCI Thesaurus)

Subsequently, aminoflavone is metabolized to toxic metabolites by the cytochromome P450 enzymes that it induces; these toxic metabolites covalently bind to DNA, resulting in the phosphorylation of p53, the induction of the p53 downstream target p21Waf1/Cip1, and apoptosis.

(AFP464, NCI Thesaurus)

Like other NSAIDs (non-steroidal anti-inflammatory drugs), acetaminophen has a unique activity profile based in part on its action at its molecular targets, the cyclooxygenase enzymes that produce prostaglandins responsible for pain, fever and inflammation.

(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)

Subsequently, the Fc component of the engineered antibody targets and binds to the CD64 receptor on the dendritic cells (DCs); upon processing by DCs, the cellular immune system may be activated to induce helper T-cell and CTL immune responses against tumor cells expressing the TRP2 antigen.

(Melanoma TRP2 CTL Epitope Vaccine SCIB1, NCI Thesaurus)

In addition, binding of the IgG1 moiety of this agent to the Fc gamma receptor on the surface of natural killer (NK)cells may bridge NK cells and target T lymphocytes, initiating NK cell-mediated apoptosis of T lymphocytes.

(Alefacept, NCI Thesaurus)

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