TERMINATION

Pronunție (USA): (GB):

Traducere în limba română

termination substantiv

1. sfârşit, capăt, limită, extremitate.

2. terminare; terminaţie; desinenţă.

3. sfârşit, încheiere, concluzie.

4. (mec.) mecanism, dispozitiv final, terminal, marginal, de capăt.

Exemple de propoziții și/sau fraze:

At its termination, Colonel Dent and his party consulted in whispers for two minutes, then the Colonel called out—"Bride!"

(Jane Eyre, de Charlotte Brontë)

A substance with a structure similar to a nucleoside molecule that is capable of occupying the active catalytic site of a reverse transcriptase resulting in inhibition of enzyme function, chain termination, and inhibition of viral replication.

(Nucleoside Reverse Transcriptase Inhibitor, NCI Thesaurus)

Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

(Gemcitabine hydrochloride, NCI Thesaurus)

Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

(Gemcitabine Elaidate, NCI Thesaurus)

I assure you, my dear boy, says Traddles, I am almost as pleased as if I were going to be married myself, to think that this event is coming to such a happy termination.

(David Copperfield, de Charles Dickens)

This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group).

(Emtricitabine, NCI Thesaurus)

Upon oral administration, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA, resulting in premature termination of DNA replication and the induction of apoptosis.

(Gemcitabine Hydrochloride Emulsion, NCI Thesaurus)

Upon intravenous administration and cellular uptake, NUC-1031 is converted into the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA replication; dFdCTP is incorporated into DNA, resulting in premature termination of DNA replication and eventually induction of apoptosis.

(Gemcitabine-Phosphoramidate Hydrochloride NUC-1031, NCI Thesaurus)

In turn, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate and triphosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA replication; dFdCTP is incorporated into DNA, resulting in premature termination of DNA replication and eventually the induction of apoptosis.

(Gemcitabine Prodrug LY2334737, NCI Thesaurus)

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