TOXIC

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toxic adjectiv

toxic.

Exemple de propoziții și/sau fraze:

The antibody binds to proteins called CD19 and CD22 on the surface of B cells, and the toxic substance kills the cells.

(Anti-CD19/Anti-CD22 Bispecific Immunotoxin DT2219ARL, NCI Dictionary)

This agent also induces apoptosis by both binding to and blocking the function of the apoptosis inhibitor protein B-cell Leukemia 2 (Bcl-2).The mucoadhesive paclitaxel formulation does not contain P-glycoprotein inhibitors, the solvent cremophor or any other toxic solvent.

(Mucoadhesive Paclitaxel Formulation, NCI Thesaurus)

The panobinostat-marizomib combination was highly toxic to DIPG cells in several models, including DIPG tumor cell cultures that represented the main genetic subtypes of the disease and mice with cells transplanted from patient tumors.

(Scientists find promising drug combination against lethal childhood brain cancers, National Institutes of Health)

Subsequently, aminoflavone is metabolized to toxic metabolites by the cytochromome P450 enzymes that it induces; these toxic metabolites covalently bind to DNA, resulting in the phosphorylation of p53, the induction of the p53 downstream target p21Waf1/Cip1, and apoptosis.

(AFP464, NCI Thesaurus)

Toxic.

(Methyl alcohol, NCI Thesaurus)

This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.

(Base Excision Repair Pathway, NCI Thesaurus/KEGG)

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