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A fusion gene that results from a chromosomal translocation t(1;11)(q21;q23) which fuses the first 6 exons of the MLL gene to the 5' untranslated region of the MLLT11 gene.

(MLL/MLLT11 Fusion Gene, NCI Thesaurus)

As an antisense molecule, ISIS 3521 hybridizes to the 3-untranslated region of the human protein kinase C (PKC-alpha) mRNA, thereby inhibiting PKC-alpha expression and growth of PKC-alpha-dependent tumor cells.

(ISIS 3521, NCI Thesaurus)

Any deletion mutation that occurs within a gene, including the 5' and 3' untranslated regions of the gene.

(Gene deletion, NCI Thesaurus)

There are at least 2 additional exons encoding the 5-prime untranslated region.

(BCSC-1, NCI Thesaurus)

A fusion gene that results from paracentric inversion of chromosome 12 which juxtaposes the first 3 exons of the HGMA2 gene with exon 13 and part of the 3' untranslated region of the ALDH2 gene.

(HMGA2/ALDH2 Fusion Gene, NCI Thesaurus)

A fusion gene that results from a chromosomal translocation t(5;12)(q31;p13) which fuses exon 1 of the ETV6 gene out-of-frame to either exon 1 or exon 11 or to the 3' untranslated region of the ACSL6 gene.

(ETV6/ACSL6 Fusion Gene, NCI Thesaurus)

Internal ribosome entry sites (IRES) were first discovered in picornavirus RNAs but it is now clear that IRESs are also present in the 5' untranslated region of many eukaryotic genes including those encoding growth factors (e.g., VEGF, FGF2 and PDGF), genes whose protein products are associated with apoptosis (e.g., Apaf-1, IXAP), transcription factors (e.g., c- myc), and the potassium channel Kv1.4.

(Internal Ribosome Entry Pathway, NCI Thesaurus/BIOCARTA)

The researchers showed that Arc mRNA and capsids travel only in a single direction between fly cells — from motor neurons to muscles — and that the Arc protein binds to a specific part of the Arc mRNA molecule called the untranslated region that is not used to make the Arc protein.

(Memory gene goes viral, National Institutes of Health)




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